Petition · Norway

Leucovorin must be available
for children in Norway.

Folinic acid (leucovorin) is used internationally for children with Cerebral Folate Deficiency — a treatable condition linked to autism. In Norway, it is not available for this indication. We are changing that.

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Why this matters

A treatable condition.
An unavailable treatment.

Cerebral Folate Deficiency (CFD) is a condition in which folate transport to the brain is blocked — often due to the presence of folate receptor antibodies (FRAT positive). It is found in a significant subset of children with autism spectrum disorder.

The treatment is folinic acid (leucovorin) — a form of vitamin B9 that bypasses the blocked receptor. It is safe, affordable, and used by paediatric neurologists in the United States, United Kingdom, and across Europe.

In Norway, leucovorin is available only for oncological use. Children with CFD cannot receive it on prescription for this indication. Families who pursue testing and treatment must do so privately, at their own cost, often travelling abroad or navigating grey-market sources. This is not acceptable.

The condition
Cerebral Folate Deficiency — folate receptor antibodies blocking brain access to folate
The treatment
Folinic acid (leucovorin) — safe, inexpensive, available internationally
The gap
Not approved for this indication in Norway. Not available on prescription. No reimbursement.
Our ask
Recognise CFD as a treatable diagnosis. Make leucovorin prescribable. Include it for reimbursement (blåresept).

We are submitting this petition to Statens legemiddelverk (Norwegian Medicines Agency) and Helsedirektoratet (Directorate of Health). Every signature adds weight. An organised community can change this.

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Add your name.

Your signature will be included in our formal submission to Norwegian health authorities.

This petition is organised by Nordic Nutrition and Metabolic Center for Child Development, org.nr 937 889 151, Sandvika, Norway.
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